Brufen 400mg Ibuprofen Tablets for Pain Relief, Fever & Inflammation – Pack of 30

Components / Key Ingredients

Ibuprofen (400mg per Tablet): The active pharmaceutical ingredient belonging to the non-steroidal anti-inflammatory drug (NSAID) class. Provides analgesic, anti-inflammatory and antipyretic effects by inhibiting cyclooxygenase enzymes and reducing prostaglandin synthesis. Helps relieve pain, reduce inflammation and lower fever.

Lactose Monohydrate (26.67mg per Tablet): An inactive excipient used as a filler to support tablet formulation and consistency. Contains lactose and may be unsuitable for individuals with certain rare hereditary disorders of sugar metabolism.

Microcrystalline Cellulose: A pharmaceutical excipient used as a binder and filler to provide tablet structure and mechanical strength.

Croscarmellose Sodium: A disintegrating agent that helps the tablet break down after swallowing, supporting the release of the active ingredient.

Colloidal Anhydrous Silica: A flow-enhancing agent that assists in maintaining consistent powder processing and tablet manufacturing.

Sodium Lauryl Sulfate: A surfactant used in the formulation to support wetting and dispersion of tablet ingredients.

Magnesium Stearate: A pharmaceutical lubricant that helps ensure smooth tablet compression and manufacturing.

Film-Coating Ingredients: Include coating materials such as Hypromellose and Titanium Dioxide, which provide the tablet's protective white film coating.

Pharmaceutical Form: White, pillow-shaped, film-coated tablets for oral administration.

Active Strength: Ibuprofen 400mg per tablet.

Pack Size: 30 Film-Coated Tablets (3 Blister Strips × 10 Tablets).

Directions for Use

Adults and Adolescents Aged 12 Years and Above:

• Take Brufen 400mg Tablets strictly according to the dosage prescribed by your doctor or recommended by your pharmacist.

• For short-term pain or fever relief, a commonly used adult dose is 400mg (one tablet), with at least 4–6 hours between doses as required.

• Without specific medical supervision, do not exceed 1200mg (three 400mg tablets) in 24 hours.

• For inflammatory conditions, a physician may prescribe higher divided doses based on individual treatment requirements.

• The UAE prescribing information permits up to 2400mg daily in certain severe conditions under medical supervision. Do not use higher doses without a prescription.

• Use the lowest effective dose for the shortest duration necessary to control symptoms.

Children Below 12 Years:

• Brufen 400mg Tablets are not suitable for children below 12 years of age.

• Use an age-appropriate paediatric ibuprofen formulation when recommended by a healthcare professional.

• Children's doses must be calculated according to body weight and medical requirements.

Method of Administration:

• Swallow the tablet whole with a full glass of water.

• Take preferably with or after food, particularly if you have a sensitive stomach.

• Do not crush, chew, break or suck the tablets.

• Maintain adequate fluid intake during treatment.

Duration of Treatment:

• Use for the shortest period necessary to relieve pain or fever.

• Seek medical advice if fever persists for more than 3 days, pain continues or symptoms worsen.

• Long-term use for arthritis or other inflammatory conditions requires medical supervision and appropriate monitoring.

Precautions & Warnings

Allergies and Hypersensitivity:

• Do not take Brufen if you are allergic to Ibuprofen, Aspirin or other NSAIDs.

• Avoid use if you have previously experienced asthma attacks, wheezing, hives, facial swelling or severe allergic reactions after taking NSAIDs.

• Discontinue use and seek immediate medical attention if breathing difficulties, swelling or severe allergic reactions occur.

Gastrointestinal Conditions:

• Ibuprofen may cause stomach irritation, indigestion, nausea, ulcers or gastrointestinal bleeding.

• Do not use if you have active or recurrent peptic ulcers or a history of NSAID-associated gastrointestinal bleeding or perforation.

• Seek immediate medical care if you experience vomiting blood, black stools or severe abdominal pain.

• Older adults are at increased risk of serious gastrointestinal complications.

Heart, Kidney and Liver Conditions:

• Consult a physician before use if you have hypertension, heart disease, kidney impairment, liver disease or fluid retention.

• NSAIDs may increase cardiovascular risks, particularly when taken at high doses or for prolonged periods.

• Avoid use in severe heart failure, severe kidney failure or severe liver failure.

• Dehydration may increase the risk of kidney-related adverse effects.

Pregnancy and Breastfeeding:

• Do not use during the third trimester of pregnancy.

• From approximately 20 weeks of pregnancy, NSAIDs may cause serious fetal kidney complications and reduced amniotic fluid. Avoid use unless specifically directed by a healthcare professional.

• During earlier pregnancy, use only when considered necessary by a physician.

• Ibuprofen passes into breast milk in small quantities. Breastfeeding women should consult a healthcare professional before use.

• Ibuprofen may temporarily affect female fertility and should be used cautiously by women trying to conceive.

Medicine Interactions:

• Do not combine with other NSAIDs such as Diclofenac, Naproxen or other Ibuprofen-containing medicines unless specifically prescribed.

• Consult a healthcare professional if taking Aspirin, blood thinners, corticosteroids, antidepressants, blood pressure medicines, diuretics, Lithium or Methotrexate.

• Combining NSAIDs with anticoagulants, antiplatelet medicines or certain antidepressants may increase the risk of gastrointestinal bleeding.

• Avoid excessive alcohol consumption during treatment.

Lactose Warning:

• Contains Lactose Monohydrate.

• Patients with rare hereditary galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Possible Side Effects

Common Side Effects:

• Indigestion, heartburn or stomach discomfort.

• Nausea, vomiting or abdominal pain.

• Diarrhoea or constipation.

• Headache, dizziness or tiredness.

Serious Side Effects:

• Gastrointestinal ulceration or bleeding.

• Severe allergic reactions or breathing difficulties.

• Kidney or liver problems.

• Severe skin reactions, including blistering or peeling.

• Cardiovascular complications, particularly with high-dose or prolonged treatment.

Stop taking the medicine and seek medical attention if serious or unusual symptoms occur.

Storage Instructions

• Store in a dry place below 30°C.

• Protect from moisture, direct sunlight and excessive heat.

• Keep tablets in their original blister packaging until required.

• Do not use after the expiry date printed on the packaging.

• Keep out of the sight and reach of children.

Important: Brufen 400mg is an NSAID medicine that should be used according to a doctor's prescription or pharmacist's instructions. Do not exceed the prescribed dosage or combine with other anti-inflammatory medicines without medical advice.

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